Contact us
Address: 2nd Eftimie Murgu Sq., 300041, Timișoara
Phone: 0256494604
E-mail: trandafirescu.cristina@umft.ro
Staff of the Academic Department
Head of the Academic Department
Members
📲 Phone: 0256494604
📧 E-mail: mara.bogdan@umft.ro
📃 Curriculum vitae
📲 Phone: 0256494604
📧 E-mail: daiana.handa@umft.ro
📃 Curriculum vitae
General presentation
Pharmaceutical Chemistry aims to study the medicinal substances used in therapy, in terms of methods of obtention, physico-chemical properties, pharmacological properties and chemical structure – biological activity relationships, as well as the design and obtaining of new chemical structures with potential pharmacological effect.
Within the discipline of Pharmaceutical Chemistry, the knowledge acquired by students in fundamental disciplines such as inorganic chemistry, organic chemistry, analytical chemistry and physical chemistry are used, and the new notions aquired will be further used by students, for the study of specialized disciplines such as pharmacology and toxicology.
Within the discipline of Pharmaceutical Chemistry was included, starting with the academic year 2021-2022, the discipline of Biochemistry. The Biochemistry discipline aims to provide the necessary information for understanding the biochemical processes that take place in the human body, the relationships between them and the mechanisms of action, at the cellular level of drugs.
The educational offer includes the following compulsory courses and practical works:
- Pharmaceutical chemistry – IIIrd year, study programs Pharmacy and Pharmacy (in French)
- Therapeutic chemistry – IVth year, study programs Pharmacy and Pharmacy (in French)
- Pharmaceutical biochemistry – IIIrd year, study programs Pharmacy and Pharmacy (in French)
- Therapeutic chemistry – IInd year, study program Pharmacy Assistance (in Lugoj)
- Descriptive and metabolic biochemistry – IInd year study program Pharmacy Assistance (in Lugoj)
- Chemistry of cosmetic and pharmaceutical ingredients – IInd year, study program Medical Cosmetics and Cosmetic Product Technology
- Notions of biochemistry – IInd year, study program Medical Cosmetics and Cosmetic Product Technology
Research topics
The research activity of the discipline members focuses mainly on the optimization of the pharmacological properties of natural and synthetic substances with biological activity, as follows:
- Synthesis and physico-chemical evaluation of some synthetic and semisynthetic compounds, with antimicrobial and anticancer activity
- Obtaining and analysis of nanostructures and complexes with cyclodextrins of biological active substances with potential antitumor action
- Physico-chemical analysis and pharmacological profile of some biological active substances
Research projects
- Project 1EXP/1233/30.01.2020 LUPSKINPATH “Lupeol as bioactive natural compound in the local treatment of wounds and inflammation from mild to severe pathologies: experimental evaluations and market pre-proposal”, 2020-2021
- Bridge project, PN-III-P2-2.1-BG-2016-0354, Formulations based on betulin and gold nanoparticles in combating the skin aging process, director prof. Codruţa Şoica, members: assoc. prof. Cristina Trandafirescu, lecturer Marius Mioc, lecturer. Roxana Ghiulai
- PII-C5-TC-2017 “Synthesis and preliminary analysis of new derivatives of 3-mercapto,1,2,4-triazole with potential antitumor effect”, director lecturer. Marius Mioc
- Ro-Hu bilateral project, contract 674 – 2013, Evaluation of modern pharmaceutical forms obtained by complexing some pentacyclic triterpenes with functionalized polysaccharide derivatives – director prof. Codruţa Şoica, members: lecturer Cristina Trandafirescu
- PN II, 665/2013, Impact assessment of UV radiation and antitumor therapy on dermal fibroblasts and in experimental skin cancer – director prof. Cristina Dehelean, member prof. Codruta Soica
- Bilateral Ro-France – RO-FR 789/30.06.2014, Nanostructures with aurones, chalcones and standardized vegetal extracts: development of a new prototype of anti-inflammatory and chemopreventive agent – director prof. Diana Antal, member prof. Codruta Soica
- Bilateral RO-FR 791/30.06.2014, Obtaining micro-crystals of pentacyclic triterpenes and studying their modifications – director lecturer Mirela Nicolov, member prof. Codruta Soica
- PN-II- 110/2014, Advanced recovery of useful products from used catalysers wastes (REMACAT) – responsible for UMFT prof. Georgeta Simu, member prof. Codruta Soica
- PN II code 1257/2007 Study of implementation of vegetal antitumor bioproducts of triterpenic type by nanostructure formation, in skin therapies, by efficacy/toxicity analysis – director prof. Cristina Dehelean , member prof. Codruţa Şoica
- AT 173/ 2007 Elaboration of bioproducts with triterpenic compounds and cyclodextrins and their efficacy/toxicity analysis in skin pathologies – director prof. Cristina Dehelean, member prof. Codruţa Şoica
- PN II PHYTOMEDAS INNOVATION PROJECT, 69/2007 – director prof. dr. Cristina Dehelean, member prof. Codruţa Şoica
- ET 35/2006 Biotechnologies for bioproducts preparation using the valorification of vegetal indicators of metals from soil – director Monica Butnariu USAMVBT, member prof. Codruţa Şoica
- Bilateral project RO-China, 198/2009 – Antioxidant activity of chinese materia medica and its chemical composition – director prof. Cristina Dehelean, member prof. Codruţa Şoica
National collaborations
- “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, Târgu Mureș, Faculty of Pharmacy
- “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Faculty of Pharmacy
- University of MEdicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy
International collaborations
- Szeged University, Faculty of Pharmacy, Hungary
- Saarland University, Saarbrucken, Germany
Representative publications
- Milan A., Mioc A., Prodea A., Mioc M., Buzatu R., Ghiulai R., Racoviceanu R., Caruntu F., Șoica C. (2022). The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges. International Journal of Molecular Sciences, 23: 1140, DOI:10.3390/ijms23031140.
- Prodea A., Mioc A., Banciu C., Trandafirescu C., Milan A., Racoviceanu R., Ghiulai R., Mioc M., Șoica C (2022). The Role of Cyclodextrins in the Design and Development of Triterpene-Based Therapeutic Agents. International Journal of Molecular Sciences, 23: 736, DOI:10.3390/ijms23031140.
- Smirnova, I., Draghici, G., Kazakova, O., Vlaia, L., Avram, S., Mioc, A., Mioc, M., Macasoi, I., Dehelean, C., Voicu, A., & Șoica, C. (2022). Hollongdione arylidene derivatives induce antiproliferative activity against melanoma and breast cancer through pro-apoptotic and antiangiogenic mechanisms. Bioorganic Chemistry, 119, 105535, ISSN 1090-2120, IF=5.275.
- Kazakova, O., Racoviceanu, R., Petrova, A., Mioc, M., Militaru, A., Udrescu, L., Udrescu, M., Voicu, A., Cummings, J., Robertson, G., Ordway, D. J., Slayden, R. A., & Șoica, C. (2021). New Investigations with Lupane Type A-Ring Azepane Triterpenoids for Antimycobacterial Drug Candidate Design. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(22), ISSN 1422-0067.
- Şoica C, Voicu M, Ghiulai R, Dehelean C, Racoviceanu R, Trandafirescu C; Roșca OJ, Nistor G, Mioc M, Mioc A. Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents. Front. Endocrinol. 2021, 11, ISSN 1664- 2392.
- Ghiulai, R., Rosca, O. J., Antal, D. S., Mioc, M., Mioc, A., Racoviceanu, R., Macasoi, I., Olariu, T., Dehelean, C., Cretu, O. M., Voicu, M., & Șoica, C. (2020). Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches. MOLECULES, 25(23), ISSN 1420-3049.
- Kazakova, O., Lopatina, T., Giniyatullina, G., Mioc, M., & Șoica, C. (2020). Antimycobacterial activity of azepanobetulin and its derivative: In vitro, in vivo, ADMET and docking studies. BIOORGANIC CHEMISTRY, 104, ISSN 0045-2068, IF= 5.275.
- Racoviceanu, R., Trandafirescu, C., Voicu, M., Ghiulai, R., Borcan, F., Dehelean, C., Watz, C., Aigner, Z., Ambrus, R., Coricovac, D. E., Circioban, D., Mioc, A., Szuhanek, C.A., & Șoica, C. (2020). Solid Polymeric Nanoparticles of Albendazole: Synthesis, Physico-5 Chemical Characterization and Biological Activity. MOLECULES, 25(21), ISSN 1420-3049.
- Mioc Alexandra, Mioc Marius, Ghiulai Roxana, Voicu Mirela, Babuta Roxana, Trandafirescu Cristina, Dehelean Cristina, Coricovac Dorina, Soica Codruța, Gold nanoparticles as targeted delivery systems and theranostic agents in cancer therapy. Curr Med Chem. 2019 May 6. doi: 10.2174/0929867326666190506123721. [Epub ahead of print].
- Marius Mioc, Sorin Avram, Vasile Bercean, Ludovic Kurunczi, Roxana Ghiulai, Camelia Oprean, Dorina Coricovac, Cristina Dehelean, Alexandra Mioc, Mihaela Balan-Porcarasu, Calin Tatu, Codruta Soica, Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer, Frontiers In Chemistry, 6, Article Number: 373, 2018
- Marius Mioc, Ioana Zinuca Pavel, Roxana Ghiulai, Dorina E. Coricovac, Claudia Farcaş, Ciprian-Valentin Mihali, Camelia Oprean, Vlad Serafim, Ramona A. Popovici, Cristina A. Dehelean, Michael I. Stihlman, Aristidis M. Tsatsakis, Codruţa Şoica. The Cytotoxic Effects of Betulin-Conjugated Gold Nanoparticles as Stable Formulations in Normal and Melanoma Cells. Frontiers In Pharmacology, 2018, Art. Nr.429; FI 4,4; DOI: 10.3389/fphar.2018.00429.
- Codruta Soica, Iulia Pinzaru, Cristina Trandafirescu, Florina Andrica, Corina Danciu, Marius Mioc, Dorina Coricovac1, Cassian Sitaru, Cristina Dehelean. Silver-, gold-, and iron-based metallic nanoparticles: Biomedical applications as theranostic agents for cancer. ELSEVIER, Design of Nanostructures for Theranostics Applications. 2018. ISBN: 978-0-12-813669-0
- Marius Mioc, Codruta Soica, Vasile Bercean, Sorin Avram, Mihaela Balan‑Porcarasu, Dorina Coricovac, Roxana Ghiulai, Delia Muntean, Florina Andrica, Cristina Dehelean, Demetrios A. Spandidos, Aristides M. Tsatsakis, Ludovic Kurunczi. Design, synthesis and pharmaco-toxicological assessment of 5-mercapto-1,2,4-triazole derivatives with antibacterial and antiproliferative activity. International Journal of Oncology, 2017, 50(4), 1175-83; FI 3,079; DOI: 10.3892/ijo.2017.3912.
- Stefana Avram, Roxana Ghiulai, Ioana Zinuca Pavel, Marius Mioc, Roxana Babuta, Mirela Voicu, Dorina Coricovac, Corina Danciu, Cristina Dehelean, Codruta Soica. Phytocompounds targeting cancer angiogenesis using the chorioallantoic membrane assay. INTECH, Phytochemistry – Natural Products and Cancer. 2017. ISBN 978-953-51-5277-4.
- Camelia Oprean, Marius Mioc, Erzsébet Csányi, Rita Ambrus, Florina Bojin, Calin Tatu, Mirabela Cristea, Alexandra Ivan, Corina Danciu, Cristina Dehelean, Virgil Paunescu, Codruta Soica. Improvement of ursolic and oleanolic acids’ antitumor activity by complexation with hydrophilic cyclodextrins. Biomedicine & Pharmacotherapy, 2016, 83: 1095-110; FI 2,759; DOI: 10.1016/j.biopha.2016.08.030.
- Codruta Soica, Adriana Fuliaş, Gabriela Vlase, Cristina Dehelean, Titus Vlase, Ionuţ Ledeţi, Synthesis and thermal behavior of new ambazone complexes with some transitional cations, J Ther Anal Cal, 2014, 118(2): 1305-1311
- Soica, C.; Danciu, C.; Savoiu-Balint, G.; Borcan, F.; Ambrus, R.; Zupko, I.; Bojin, F.; Coricovac, D.; Ciurlea, S.; Avram, S.; Dehelean, C.A.; Olariu, T.; Matusz, P. Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells. Int. J. Mol. Sci. 2014, 15, 8235-8255.
- Codruţa Şoica, Camelia Oprean, Florin Borcan, Corina Danciu, Cristina Trandafirescu, Dorina Coricovac, Zorin Crăiniceanu, Cristina Dehelean, Melania Munteanu, The synergistic biologic activity of oleanolic and ursolic acids in complex with hydroxypropyl-γ-cyclodextrin, Molecules 2014, 19, 4924-4940
- Codruţa Şoica, Cristina Trandafirescu, Corina Danciu, Danina Muntean, Cristina Dehelean, Georgeta Simu – New Improved Drug Delivery Technologies for Pentacyclic Triterpenes: A Review, Protein Pept Lett, 2014, vol. 21, nr. 11, 1137-1145
- Cristina Trandafirescu, Árpád Gyéresi, Zoltán Szabadai, Mihály Kata, Zoltán Aigner – Solid-state characterization of bifonazole – beta-cyclodextrin binary systems. Note I, Farmacia, vol. 62, nr. 3, 2014, 521-531
- Cristina Trandafirescu, Gyéresi Á., Szabadai Z., Pătruţescu C., Kata M., Aigner Z., – Solid-state characterization of bifonazole – random methyl-beta-cyclodextrin binaez systems, Farmacia, vol. 61, nr. 3, p. 609-616, 2013
- Codruta Şoica, Cristina Dehelean, Corina Danciu, Hai Ming Wang, Gerhard Wenz, Rita Ambrus, Florina Bojin and Mariana Anghel, Betulin Complex in γ-Cyclodextrin Derivatives: Properties and Antineoplasic Activities in In Vitro and In Vivo Tumor Models, Int. J. Mol. Sci. 2012, 13(11), 14992-15011
- M. Wang, C. Soica, G. Wenz, A comparison investigation on the solubilization of betulin and betulinic acid in cyclodextrin derivatives, Nat Prod Comm, 2012, 7(3): 289-291.
- Şoica C, Peev C, Dehelean C, Aluas M, Zupko I, Kasa Peter, Alexa E, Physico-chemical comparison study of betulinic acid, betulin and birch bark extract and in vitro investigation of their cytotoxic effects towards skin epidermoid carcinoma (A431), breast carcinoma (MCF7) and cervix adenocarcinoma (HeLa) cell-lines, Natural Product Research, 2012, 26(10): 968-974
Books elaborated by the discipline team
- Cristina Trandafirescu, Florin Borcan, Cristina Pătruțescu. Chimie pharmaceutique- Travaux pratiques, Ed. Mirton 2021
- Cristina Trandafirescu, Roxana Racoviceanu, Marius Mioc, Roxana Ghiulai. Chimie farmaceutică- Lucrări de laborator, Ed. Mirton 2021
- Codruţa Şoica, Florin Borcan, Cristina Trandafirescu, Chimia şi acţiunea antisepticelor şi dezinfectantelor, Ed. Victor Babeş Timişoara, 2013
- Codruţa Şoica, Cristina Trandafirescu, Chimie Farmaceutică: Medicaţia aparatelor şi sistemelor. Vol. I, Ed. Victor BabeşTimişoara, 2013
- Cristina Trandafirescu, Laura Sbârcea. Chimie farmaceutică. Chimioterapice antiinfecțioase, Ed. Mirton, Timișoara, 2011
- Codruţa Şoica, Chimie farmaceutică. Terapia cu antibiotice antibacteriene, Ed. Mirton, Timişoara, 2007
- Codruţa Şoica, Cristina Trandafirescu, Cristina Pătruţescu – Chimie Farmaceutică. Lucrări practice de laborator, Ed. Mirton, Timişoara, 2008.