Catedra universitară Farmacologie – Farmacoterapie

Manifestări științifice organizate de disciplină

• Workshop New trends in pharmaceutical research; Timișoara, 2023

Capitole publicate in edituri nationale:

• Mirela Voicu, Cristiana Mabda – Capitolul 53 (Epilepsia); Maria Suciu, Valentina Buda – Capitolul 57 (Statusul epileptic); Carmen Cristescu, Liana Suciu – Capitolul 77 (Astmul bronşic) în: Wells Barbara G, Schwinghammer Terry L., DiPiro Joseph T., DiPiro Cecily V.; coordonatorul editiei in limba română Adina Popa; Manual de farmacoterapie. Editia a zecea, Editura Prior & Books, 2019; ISBN 978-973-88039-3-0

Carti publicate

• Codruța Șoica, Roxana Negrea Ghiulai, Alexandra Mioc, Liana Suciu, Maria Cristiana MabdaFarmacologie – Farmacoterapie. Note de curs. Vol I. Editura Victor Babes, ISBN 978-606-786-370-3
• Diana Uțu, Alina Jojic, Mirela Voicu, Sergio Liga. Microbiologie Generala. Sinteze de curs. Editura Victor Babes, ebook ISBN 978-606-786-377-2
• Alexandra Mioc, Germaine Săvoiu-Balint. Anatomie, fiziologie si fiziopatologie. Note de curs pentru Asistentii de farmacie. Editura Victor Babes, Timisoara, 2021. ISBN 978-606-786-257-7
• Alexandra Mioc, Germaine Săvoiu-Balint. Anatomy, Physiology and Pathophysiology Course notes for pharmacy students. Editura Victor Babes, Timisoara, 2023. ISBN 978-606-786-315-4.
• Alexandra Mioc, Germaine Săvoiu-Balint. Anatomie, fiziologie, fiziopatologie. Note de curs pentru studenții facultății de farmacie. Editura Victor Babes, Timisoara, 2023. ISBN 978-606-786-316-1.
• Mirela Voicu, Adrian Voicu, Gabriela Antal. Imunologie. Curs pentru studenții Facultății de Farmacie. Editura Victor Babes, Timisoara, 2023. ISBN 978-606-786-382-6
• Anca Dragomirescu, Germaine Săvoiu-Balint, Maria Suciu, Felicia Andrei, Carmen Tomoroga. Teste de Biologie pentru admiterea la Facultatea de Farmacie. Editura „Victor Babeș”, Timișoara, 2021
• Anca Dragomirescu, Germaine Săvoiu-Balint, Maria Suciu, Felicia Andrei, Carmen Tomoroga. Teste de Biologie pentru admiterea la Facultatea de Farmacie. Editura „Victor Babeș”, Timișoara, 2020.

 Capitole publicate in edituri internationale

• Soica C, Pinzaru I, Trandafirescu C, Andrica F, Danciu C, Mioc M, Coricovac D, Sitaru C, Dehelean C. Silver-, gold-, and iron-based metallic nanoparticles: Biomedical applications as theranostic agents for cancer. In: “Design of Nanostructures for Theranostics Applications”, book edited by Alexandru Mihai Grumezescu, ISBN: 978-0-12-813669-0, Elsevier 2018, pp. 161-242.
• Alaeddin Abukabda, Maria Suciu, Minodora Andor. Book: Cardiovascular Risk Factors in Pathology. InTechOpen, London, United Kindom, 2021. ISBN 978-1-83881-949-1
• Maria Suciu, Carmen Cristescu. Psychosomatic Interrelations in Cardiovascular Diseases and Their Consequences on Patient’s Quality of Life. Book: Well-Being and Quality of Life – Medical Perspective (Mukadder Mollaoglu) InTechOpen, Croatia, 2017. ISBN 978-953-51-3513-5

Publicațiile disciplinei

• Liana Suciu, Sebastian Mihai Ardelean, Mihai Udrescu, Florina-Diana Goldi, Daiana Hânda, Maria-Medana Tuică, Sabina-Oana Vasii and Lucreția Udrescu. Categorical Analysis of Database Consistency in Reporting Drug–Drug Interactions for Cardiovascular Diseases. Pharmaceutics 2024, 16, 339. https://doi.org/10.3390/pharmaceutics1603033
• Milan, A.; Mioc, M.; Mioc, A.; Marangoci, N.; Racoviceanu, R.; Mardale, G.; Bălan-Porcărașu, M.; Rotunjanu, S.; Şoica, I.; Șoica, C. Exploring the Antimelanoma Potential of Betulinic Acid Esters and Their Liposomal Nanoformulations. Processes 2024, 12, 416. https://doi.org/10.3390/pr12020416
• Oana Budu, Alexandra Mioc* (*corresponding author), Codruta Soica, Florina Caruntu, Andreea Milan, Camelia Oprean, Daniel Lighezan, Slavita Rotunjanu, Viviana Ivan  and Christian Banciu. Lactiplantibacillus plantarum Induces Apoptosis in Melanoma and Breast Cancer Cells. Microorganisms 2024, 12, 182. https://doi.org/10.3390/microorganisms12010182. FI 4.926
• Alexandra Prodea, Andreea Milan, Marius Mioc, Alexandra Mioc, Camelia Oprean, Roxana Racoviceanu, Roxana Negrea-Ghiulai, Gabriel Mardale, Stefana Avram, Mihaela Balan-Porcărasu, Slavitta Rotunjanu, Cristina Trandafirescu, Irina Soica and Codruta Soica. Novel Betulin-1,2,4-Triazole Derivatives Promote In Vitro Dose-Dependent Anticancer Cytotoxicity. Processes 2024, 12, 24. https://doi.org/10.3390/pr12010024. FI: 3.5
• Oana Budu, Christian Dragos Banciu, Codruta Soica, Daniel Florin Lighezan, Andreea Milan, Alexandra Prodea, Alexandra Mioc, Marius Mioc, Gabriel Mardale, Laurentiu Sima. Lacticaseibacillus rhamnosus—A Promising Tool for Colorectal Cancer Treatment. Processes 2023, 11(3), 781; DOI10.3390/pr11010101. FI: 3.5
• Jianu C., Lukinich-Gruia A.T., Rădulescu M., Mioc M., Mioc A., Șoica C., Constantin A.T., David I., Bujancă G., Radu R.G. Essential Oil of Origanum vulgare var. aureum L. from Western Romania: Chemical Analysis, In Vitro and In Silico Screening of Its Antioxidant Activity. (2023) Applied Sciences (Switzerland), 13 (8). DOI: 10.3390/app13085076 FI: 2.7
• Rotunjanu, S; Racoviceanu, R; Mioc, A; Milan, A; Negrea-Ghiulai, R; Mioc, M; Marangoci, NL; Soica, C. Newly Synthesized CoFe2-xDyxO4 (x=0; 0.1; 0.2; 0.4) Nanoparticles Reveal Promising Anticancer Activity against Melanoma (A375) and Breast Cancer (MCF-7) Cells. Int J Mol Sci, 2023, 24(21), DOI10.3390/ijms242115733. FI: 5.6
• Patricia-Andrada Reștea, Mariana Mureșan, Adrian Voicu*, Tunde Jurca, Annamaria Palage, Eleonora Marian, Laura Grațiela Vicaș, Ionuț I Jeican, Carmen-Bianca Crivii, Antidiabetic Treatment before Hospitalization and Admission Parameters in Patients with Type 2 Diabetes, Obesity, and SARS-CoV-2 Viral Infection, Journal of Personalized Medicine, 2023, IF = (*corresponding author)
• Gabriela Nistor, Alexandra Mioc* (*corresponding author), Marius Mioc, Mihaela Balan-Porcarasu, Roxana Ghiulai, Roxana Racoviceanu, Ștefana Avram, Alexandra Prodea, Alexandra Semenescu, Andreea Milan, Cristina Dehelean and Codruța Șoica. Novel Semisynthetic Betulinic Acid−Triazole Hybrids with In Vitro Antiproliferative Potential. Processes. 2023, 11, 101. https://doi.org/10.3390/pr11010101. FI: 3.5
• Mioc, M.; Mioc, A.* (*corresponding author), Racoviceanu, R.; Ghiulai, R.; Prodea, A.; Milan, A.; Barbu Tudoran, L.; Oprean, C.; Ivan, V.; Șoica, C. The Antimelanoma Biological Assessment of Triterpenic Acid Functionalized Gold Nanoparticles. Molecules 2023, 28, 421. https://doi.org/10.3390/molecules28010421 FI: 4.6- yellow area (according to the JCR 2021 IF/AIS classification).
• Roxana Ghiulai , Marius Mioc , Roxana Racoviceanu , Alexandra Prodea , Andreea Milan, Dorina Coricovac , Cristina Dehelean ¸ Stefana Avram, Alina D. Zamfir, Cristian V. A. Munteanu ,Viviana Ivan Codruta  Soica. Structural Investigation of Betulinic Acid Plasma Metabolites by Tandem Mass Spectrometry. Molecules 2022, 27, 7359.. Impact Factor=  4.6
• Ghiulai, R.; Mioc A* (corresponding author); Racoviceanu, R.; Mioc, M.; Milan, A.; Prodea, A.; Semenescu, A.; Dehelean, C.; Barbu Tudoran, L.; Avram, Ș.; Trandafirescu, C.; Șoica, C. The Anti-Melanoma Effect of Betulinic Acid Functionalized Gold Nanoparticles: A Mechanistic In Vitro Approach. Pharmaceuticals 2022, 15, 1362. https://doi.org/10.3390/ph15111362 FI: 4.6- red area (according to the JCR 2021 IF/AIS classification).
• Mioc M, Mioc A* (corresponding author), Prodea A, Milan A, Balan-Porcarasu M, Racoviceanu R, Ghiulai R, Iovanescu G, Macasoi I, Draghici G, Dehelean C, Soica C. Novel Triterpenic Acid-Benzotriazole Esters Act as Pro-Apoptotic Antimelanoma Agents. Int J Mol Sci. 2022 Sep 1;23(17):9992. doi: 10.3390/ijms23179992. FI: 5.6 – yellow area (according to the JCR 2021 IF/AIS classification). 
• Andreea Igna, Cornel Igna, Mariana Ioana Miron, Larisa Schuszler, Roxana Dascălu, Mihaela Moldovan, Adrian Aristide Voicu, Carmen Darinca Todea, Marius Boariu, Maria-Alexandra Mârțu, Ștefan-Ioan Stratul, Assessment of Pulpal Status in Primary Teeth Following Direct Pulp Capping in an Experimental Canine Model, Diagnostics 2022, Volumul 12, Numărul 8, IF=3.992
• Viorelia Radulescu, Marius Ion Boariu, Darian Rusu, Alexandra Roman, Petra Surlin, Adrian Voicu, Andreea Cristiana Didilescu, Holger Jentsch, Vincenzo Iorio Siciliano, Luca Ramaglia, Octavia Vela, Giorgios Kardaras, Anton Sculean, Stefan-Ioan Stratul, Clinical and microbiological effects of a single application of sodium hypochlorite gel during subgingival re-instrumentation: A triple-blind randomized placebo-controlled clinical trial, Clinical Oral Investigation 2022, 26, 6639-6652, IF= 3.734
• Irina Smirnova, George Draghici, Oxana Kazakova, Lavinia Vlaia, Stefana Avram, Alexandra Mioc, Marius Mioc, Ioana Macasoi, Cristina Dehelean, Adrian Voicu, Codruta Soica. Hollongdione arylidene derivatives induce antiproliferative activity against melanoma and breast cancer through pro-apoptotic and antiangiogenic mechanisms. Bioorganic Chemistry. 2022; 119:105535. DOI10.1016/j.bioorg.2021.105535 FI: 5.307. – yellow area (according to the JCR 2021 IF/AIS classification).
• Alexandra Prodea†, Alexandra Mioc† (†Authors with equal contribution), Christian Banciu*, Cristina Trandafirescu,* Andreea Milan, Roxana Racoviceanu, Roxana Ghiulai, Marius Mioc, Codruta Soica. The role of cyclodextrins in the design and development of 2 triterpene-based therapeutic agents. Int J Mol Sci. 2022;22. FI: 5.6- yellow area (according to the JCR 2021 IF/AIS classification).
• Mioc M, Milan A, Malița D*, Mioc A*(*corresponding author), Prodea A, Racoviceanu R, Ghiulai R, Cristea A, Căruntu F, Șoica C. Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I). Int J Mol Sci. 2022 Jul 13;23(14):7740. doi: 10.3390/ijms23147740. FI: 5.6- yellow area (according to the JCR 2021 IF/AIS classification).
• Nistor G, Trandafirescu C, Prodea A, Milan A, Cristea A, Ghiulai R, Racoviceanu R, Mioc A, Mioc M, Ivan V, Șoica C. Semisynthetic Derivatives of Pentacyclic Triterpenes Bearing Heterocyclic Moieties with Therapeutic Potential. Molecules. 2022 Oct 3;27(19):6552. doi: 10.3390/molecules27196552 FI: 4.6- yellow area (according to the JCR 2021 IF/AIS classification).
• Gabriela Nistor, Marius Mioc, Alexandra Mioc, Mihaela Balan-Porcarasu, Roxana Racoviceanu, Alexandra Prodea, Andreea Milan, Roxana Ghiulai, Alexandra Semenescu, Cristina Dehelean, Codruța Șoica. The C30-Modulation of Betulinic Acid Using 1, 2, 4-Triazole: A Promising Strategy for Increasing Its Antimelanoma Cytotoxic Potential. Molecules 2022, 27(22), 7807; DOI10.3390/molecules27227807 FI: 4.6 – yellow area (according to the JCR 2021 IF/AIS classification).
• Mioc M, Prodea A, Racoviceanu R*, Mioc A*(*corresponding author), Ghiulai R, Milan A, Voicu M, Mardale G, Șoica C. Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II). Int J Mol Sci. 2022 Aug 10;23(16):8896. doi: 10.3390/ijms23168896 FI: 5.6 – yellow area (according to the JCR 2021 IF/AIS classification).
• Vlad Tiberiu Alexa, Atena Galuscan, Codruța M Soica, Antoanela Cozma, Dorina Coricovac, Florin Borcan, Iuliana Popescu, Alexandra Mioc, Camelia Szuhanek, Cristina Adriana Dehelean, Daniela Jumanca. In vitro assessment of the cytotoxic and antiproliferative profile of natural preparations containing bergamot, orange and clove essential oils. Molecules 2022, 27(3), 990; DOI10.3390/molecules27030990. FI: 4.6- yellow area (according to the JCR 2021 IF/AIS classification).
• Milan A*, Mioc A* (*authors with equal contribution), Prodea A, Mioc M, Buzatu R, Ghiulai R, Racoviceanu R, Caruntu F, Şoica C. The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges. Int J Mol Sci. 2022 Jan 20;23(3):1140. doi: 10.3390/ijms23031140 FI: 5.6 –  yellow area (according to the JCR 2021 IF/AIS classification).
• Jianu, C.; Rusu, L.-C.; Muntean, I.; Cocan, I.; Lukinich-Gruia, A.T.; Goleț, I.; Horhat, D.; Mioc, M.; Mioc, A.; Șoica, C.; Bujancă, G.; Ilie, A.C.; Muntean, D. In Vitro and In Silico Evaluation of the Antimicrobial and Antioxidant Potential of Thymus pulegioides Essential Oil. Antioxidants 2022, 11, 2472. DOI10.3390/antiox11122472.  FI: 7- red area (according to the JCR 2021 IF/AIS classification).
• Codruta Soica, Mirela Voicu, Roxana M. Ghiulai, Cristina Dehelean, Roxana Racoviceanu, Cristina Trandafirescu, Oana Rosca, Gabriela Nistor, Mioc Marius, Alexandra Mioc. Natural compounds in sex hormone-dependent cancers: the role of triterpenes as therapeutic agents. Frontiers in Endocrinology. 2021; 11: 612396. DOI: 10.3389/fendo.2020.612396. FI: 5.555 – yellow area (according to the JCR 2021 IF/AIS classification).
• Călin Jianu, Daniela Stoin, Ileana Cocan, Ioan David, Georgeta Pop, Alexandra Teodora Lukinich-Gruia, Marius Mioc, Alexandra Mioc, Codruța Șoica, Delia Muntean, Laura-Cristina Rusu, Ionuț Goleț, Delia Ioana Horhat. In Silico and In Vitro Evaluation of the Antimicrobial and Antioxidant Potential of Mentha× smithiana R. GRAHAM Essential Oil from Western Romania. Foods. 2021; 10(4): 815. DOI10.3390/foods10040815. FI: 5.561 – yellow area (according to the JCR 2021 IF/AIS classification).
• Radulescu M, Jianu C, Lukinich-Gruia AT, Mioc M, Mioc A, Soica C, Loredana Gabriela Stana. Chemical Composition, In Vitro and In Silico Antioxidant Potential of Melissa officinalis subsp. officinalis Essential Oil. Antioxidants. 2021;10(7): 1081. DOI10.3390/antiox10071081. FI: 7.675 – red area (according to the JCR 2021 IF/AIS classification).
• Kazakova O, Șoica C, Babaev M, Petrova A, Khusnutdinova E, Poptsov A, Macasoi I, Draghici G, Avram S, Vlaia L, Mioc A, Mioc M, Dehelean C, Voicu A. 3-Pyridinylidene Derivatives of Chemically Modified Lupane and Ursane Triterpenes as Promising Anticancer Agents by Targeting Apoptosis. Int J Mol Sci. 2021;22(19):10695. DOI10.3390/ijms221910695. FI: 6.208 – yellow area (according to the JCR 2021 IF/AIS classification).
• Călin Jianu, Ionuț Goleț, Daniela Stoin, Ileana Cocan, Gabriel Bujancă, Corina Mișcă, Marius Mioc, Alexandra Mioc, Codruța Șoica, Alexandra Teodora Lukinich-Gruia, Laura-Cristina Rusu, Delia Muntean, Delia Ioana Horhat. Chemical Profile of Ruta graveolens, Evaluation of the Antioxidant and Antibacterial Potential of Its Essential Oil, and Molecular Docking Simulations. Applied Sciences. 2021;11(24): 11753. DOI10.3390/app112411753. FI: 2.838.
• Dorina Coricovac, Cristina Adriana Dehelean, Iulia Pinzaru, Alexandra Mioc* (*corresponding author), Oana-Maria Aburel, Ioana Macasoi, George Andrei Draghici, Crina Petean, Codruta Soica, Madalina Boruga, Brigitha Vlaicu, Mirela Danina Muntean. Assessment of Betulinic Acid Cytotoxicity and Mitochondrial Metabolism Impairment in a Human Melanoma Cell Line. Int J Mol Sci. 2021; 22, 4870. https://doi.org/10.3390/ijms2209487. FI: 6.208. – yellow area according to the JCR 2021 IF/AIS classification).
• Kazakova O, Mioc A*, Smirnova I, Baikova I, Voicu A, Vlaia L, et al (* authors with equal contribution). Novel Synthesized N-Ethyl-Piperazinyl-Amides of C2-Substituted Oleanonic and Ursonic Acids Exhibit Cytotoxic Effects through Apoptotic Cell Death Regulation. Int J Mol Sci. 2021;22(20):10967. FI: 6.208 – yellow area (according to the JCR 2021 IF/AIS classification).
• Minda D*, Mioc A*, Banciu C, Soica C, RacoviceanuR, Mioc M, Macasoi I, Avram S, Voicu A, Motoc A, Trandafirescu C (*Authors with equal contribution). Cyclodextin Dispersion of Mebendazole and Flubendazole Improves In Vitro Antiproliferative Activity. Processes. 2021, 9(12)2185. FI 3.352
• Liana Suciu, Maria Suciu, Mirela Voicu, Raluca Mureșan, Florina Viorica Pârv, Valentina Buda, Carmen Cristescu, Factors Influencing Adherence to Treatment and Quality of Life for a Group of Patients with Essential Hypertension in Romania, Patient Prefer Adherence.2021; 15: 483–491, doi: 2147/PPA.S269119
• Maria Suciu, Liana Suciu, Lavinia Vlaia, Mirela Voicu, Valentina Buda, Liana Drăgan, Minodora Andor, Vicenţiu Vlaia, Carmen Cristescu, Mircea Hîrjău; The prevalence of inappropriate use of NSAIDS by cardiovascular patients for musculoskeletal disorders; Farmacia, 2020, vol 68, 4; 628-639;
• Adrian Voicu, Narcis Duțeanu, Mirela Voicu, Daliborca Vlad, Victor Dumitrașcu. The rcdk and cluster R packages applied to drug candidate selection, J Cheminform, 2020, 12(3), https://doi.org/10.1186/s13321-019-0405-0, pp. 1-8, IF = 4.154
• Maria Proks, Alina Heghes, Adelina Cheveresan, Simona Nita, Mirela Voicu, Valentina Buda, Daniela Ionescu, Lucian Nita, Cristina Trandafirescu, Virgil Paunescu, Thyme Leaves Aqueous Extract and its Formulations; A comparative study based on chemical structures and biological activity, Revista de chimie, 2019, Vol 70, Number 5;
• Maria Suciu, Liana Suciu, Lavinia Vlaia, Mirela Voicu, Valentina Buda, Liana Drăgan, Minodora Andor, Vicenţiu Vlaia, Carmen Cristescu, Prevalence and the patterns of use of non-steroidal anti-inflammatory drugs (NSAIDS) and paracetamol among the general population, Farmacia, 2019, Vol. 67, 2; I
• Carmen Cristescu, Simona Negreş, Maria Suciu, Adrian Voicu, Valentina Buda, Liana Suciu, Maria Proks, Mirela Voicu. study regarding the parents’ use of self – medication among children under 12 years old. Farmacia, 2018, vol 66, 5, septembrie-octombrie, p 811-819

Proiecte

• PN-III-P2-2.1-PED-2019-3067, Nanobiostructuri inovative cu nanoparticule ferimagnetice conjugate cu ciclodextrine pentru a crește eficacitatea și a reduce toxicitatea în terapia cancerului prin hipertermie SP-magnetică. Responsabil proiect Prof. Univ. Dr. Șoica Codruța-Marinela
• CNFIS-FDI-2023-F-0450 Dezvoltarea continua a acțiunilor antreprenoriale studențești prin și pentru studenți și absolvenți în cadrul UMFVBT. Director de proiect Prof. Univ. Dr. Șoica Codruța-Marinela
• 1EXP/1233/30.01.2020, Lupeol ca compus natural bioactiv în tratamentul local al rănilor și inflamației de la patologii ușoare până la severe: evaluări experimentale și pre-propunere de piață. Director de proiect Prof. Univ. Dr. Șoica Codruța-Marinela, membru conf. Dr. Roxana Negrea-Ghiulai

Afilieri centre de cercetare

• Centru de cercetare pentru evaluări farmacotoxicologice/ acronim Farmatox, director centru: Prof. Univ. Dr. Cristina Adriana Dehelean: membri titulari : Prof. Univ. dr. Codruța Șoica, conf. Univ. Dr. Roxana Negrea-Ghiulai, colaboratorilor interni: Univ. Voicu Mirela, Conf. Univ. Mioc Alexandra Ș.l. Suciu Maria, Ș.l. Suciu Liana.